Reactivity of β-lactams and phosphonamidates and reactions with β-lactamase
نویسندگان
چکیده
منابع مشابه
Reactivity of p-lactams and phosphonamidates and reactions with P-lactamase
Themodynamicplly stnincd four membered cyclic 8-lactams do not show a corrcspondimg kinetic effect in the rates of their ring openhg reactions. Contrary to expectations. breaking the C-N bond in these mined ring seuc~ures appears to be a relatively difficult process. A four membend cyclic phosphonamidate. on the other hand, undergoes rapid hydrolysis in water with exclusive endocyclic P-N fisio...
متن کاملPharmacodynamic study of β-lactams alone and in combination with β-lactamase inhibitors against Pseudomonas aeruginosa possessing an inducible β-lactamase
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متن کاملHigh Serum β-Lactams Specific/Total IgE Ratio Is Associated with Immediate Reactions to β-Lactams Antibiotics
Total serum IgE result from the combination of specific and non-specific pools. High specific/total IgE ratio may reflect high level of allergen-specific IgE on mast cells. No data regarding its applications to drug allergies is available. One hundred seventy-one patients with a history of immediate reactions to β-lactams, confirmed by positive skin testing, and 122 control subjects tolerant to...
متن کاملIn Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Multidrug-Resistant Mycobacterium tuberculosis Isolates.
The combination of β-lactams and β-lactamase inhibitors has been shown to have potent in vitro activity against multidrug-resistant tuberculosis (MDR-TB) isolates. In order to identify the most potent β-lactam-β-lactamase inhibitor combination against MDR-TB, we selected nine β-lactams and three β-lactamase inhibitors, which belong to different subgroups. A total of 121 MDR-TB strains were incl...
متن کاملCross-reactivity and Tolerability of Ertapenem in Patients With IgE-Mediated Hypersensitivity to β-Lactams.
BACKGROUND AND OBJECTIVE Administration of carbapenems to β-lactam-allergic patients has always been considered potentially harmful because of a 47.4% rate of cross-reactivity to imipenem reported in a single study. Nevertheless, recent studies have shown that the rate of cross-reactivity of imipenem and meropenem with penicillins is lower than 1%. The aim of this study was to evaluate the poss...
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ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 1995
ISSN: 1365-3075,0033-4545
DOI: 10.1351/pac199567050711